Well Being > Supplements

Appelation Spa Products with Grapeseed

Product: NSI ActiVin® Grape Seed Extract 200 mg - 100 Caps
Manufacturer: NSI ActiVin

Regular Price: $30.95

Discounted Price: $14.99 Order Details

Daily Servings: 100    Cost per Serving: $0.15

Description:

ActiVin® is a patented form of grape seed extract which is a powerful antioxidant. Clinical trials have shown that it has more potent free-radical scavenging activity than vitamin C, vitamin E and beta-carotene. It may be more potent and effective than pine bark at a substantially lower cost.

The Scientific Advisory Board at NSI® (composed of medical doctors) has developed a revolutionary approach to bio-available technology: UltrAbsorb Technology®. It provides speedy assimilation and allows easy, gentle absorbtion of nutrients that promote your health.

About Grapeseed:

Search:Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor.

Proc Natl Acad Sci U S A, 94(25):14138-43 1997 Dec 9
The phytochemical resveratrol, which is found in grapes and wine, has been reported to have a variety of anti-inflammatory, anti-platelet, and anti-carcinogenic effects. Based on its structural similarity to diethylstilbestrol, a synthetic estrogen, we examined whether resveratrol might be a phytoestrogen. At concentrations (approximately 3-10 microM) comparable to those required for its other biological effects, resveratrol inhibited the binding of labeled estradiol to the estrogen receptor and it activated transcription of estrogen-responsive reporter genes transfected into human breast cancer cells. This transcriptional activation was estrogen receptor-dependent, required an estrogen response element in the reporter gene, and was inhibited by specific estrogen antagonists. In some cell types (e.g., MCF-7 cells), resveratrol functioned as a superagonist (i.e., produced a greater maximal transcriptional response than estradiol) whereas in others it produced activation equal to or less than that of estradiol. Resveratrol also increased the expression of native estrogen-regulated genes, and it stimulated the proliferation of estrogen-dependent T47D breast cancer cells. We conclude that resveratrol is a phytoestrogen and that it exhibits variable degrees of estrogen receptor agonism in different test systems. The estrogenic actions of resveratrol broaden the spectrum of its biological actions and may be relevant to the reported cardiovascular benefits of drinking wine.

Science, 1997 Jan, 275:5297, 218-20
Resveratrol, a phytoalexin found in grapes and other food products, was purified and shown to have cancer chemopreventive activity in assays representing three major stages of carcinogenesis. Resveratrol was found to act as an antioxidant and antimutagen and to induce phase II drug-metabolizing enzymes (anti-initiation activity); it mediated anti-inflammatory effects and inhibited cyclooxygenase and hydroperoxidase functions (antipromotion activity); and it induced human promyelocytic leukemia cell differentiation (antiprogression activity). In addition, it inhibited the development of preneoplastic lesions in carcinogen-treated mouse mammary glands in culture and inhibited tumorigenesis in a mouse skin cancer model. These data suggest that resveratrol, a common constituent of the human diet, merits investigation as a potential cancer chemopreventive agent in humans.

Red wine is powerful:
Article

Red wine has many important elements. It contains powerful antioxidants called bioflavanoids. One of the best studied is quercetin. There are numerous studies published on quercetin indicating significantly reduced risk of heart disease and stroke with increased quercetin consumption; 100 ­ 200 mg per day appears to be optimal. Red wine also contains substances known as polyphenols which inhibit oxidation of LDL cholesterol, reduce platelet stickiness (which can lead to clotting within arteries), etc. One extremely powerful polyphenol in red wine is known as resveratrol. Green tea also contains similar protective antioxidants.

I certainly enjoy having a glass of red wine from time to time. It is probably unreasonable, however, for most people to be drinking red wine on a daily basis. As a healthy alternative, I would strongly recommend standardized red wine extract, grape seed extract (Activin is the best standardized form with numerous studies behind it) and standardized green tea extract. In fact some studies indicate grape seed extract is a far more powerful antioxidant when compared to Vitamin C, E or Beta Carotene. Although we sell over 6,000 products on Vitacost, I keep coming back to the NSI line of products. This is our top flagship brand and there is a lot of time and research put into the formulation of these products by board certified medical doctors reviewing thousands of studies every year. Most of the NSI Synergy line and multinutrient products contain standardized red wine and standardized green tea extracts along with standardized grapeseed extract in the form of Activin. However, for those looking for this exact combination to add to their supplement regimen, NSI offers a product containing all three of these excellent nutrients. This product is a powerful antioxidant trio that I would highly recommend to everyone

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